Identificación de cepas de E. coli productoras de betalactamasas de espectro extendido (BLEE) aisladas en el Centro Médico ISSEMyM de Toluca
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jul 11, 2022
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https://doi.org/10.30878/ces.v29n2a5
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Euridice Ladisu Mejía-Argueta
http://orcid.org/0000-0003-0137-498X
Jonnathan Guadalupe Santillán-Benítez
http://orcid.org/0000-0003-3574-1231
José Mejía-Juárez
http://orcid.org/0000-0002-6287-0170
http://orcid.org/0000-0003-0137-498X
Jonnathan Guadalupe Santillán-Benítez
http://orcid.org/0000-0003-3574-1231
José Mejía-Juárez
http://orcid.org/0000-0002-6287-0170
Resumen
Se analizaron datos de E. coli productora de BLEEs aisladas de pacientes de diferentes áreas hospitalarias por medio de las interacciones que existen entre los antibiogramas y las áreas a través de análisis de varianza (ANOVA) de dos factores y la prueba de Bartlett para homocedasticidad. Se encontró una incidencia del 45% de E. coli y de 135 cepas muestreadas, el 4.58% fue E. coli BLEE. Además, usando una prueba de Bartlett, se determinó que existe una diferencia significativa entre las áreas y en sus pruebas fenotípicas, por lo que se deben implementar medidas de capacitación, control y prevención en el sector salud para evitar en mayor medida la propagación de infecciones entre áreas de salud pública.
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MEJÍA-ARGUETA, Euridice Ladisu; SANTILLÁN-BENÍTEZ, Jonnathan Guadalupe; MEJÍA-JUÁREZ, José.
Identificación de cepas de E. coli productoras de betalactamasas de espectro extendido (BLEE) aisladas en el Centro Médico ISSEMyM de Toluca.
CIENCIA ergo-sum, [S.l.], v. 29, n. 2, jul. 2022.
ISSN 2395-8782.
Disponible en: <https://cienciaergosum.uaemex.mx/article/view/12910>. Fecha de acceso: 18 ago. 2026
doi: https://doi.org/10.30878/ces.v29n2a5.
Sección
Ciencias de la salud humana
Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
Citas
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Cantón, R., & Cobo, J. (2009). Hospital antibiotic use and resistance: A relationship that is difficult to measure and complex to interpret. Enfermedades infecciosas y microbiologia clinica, 27(8), 437-440. https://doi.org/10.1016/j.eimc.2009.04.004
Diestra, K., Coque, T. M., Miró, E., Oteo, J., Nicolau, C. J., Campos, J., & Oliver, A. (2008). Caracterización y epidemiología molecular de betalactamasas de espectro extendido en Escherichia coli y Klebsiella pneumoniae en once hospitales españoles (2004). Enfermedades Infecciosas y Microbiología Clínica, 26(7), 404-410. https://doi.org/10.1157/13125636
Fariñas, M. C. y Martínez-Martínez, L. (2013). Infecciones causadas por bacterias gramnegativas multirresistentes: enterobacterias, Pseudomonas aeruginosa, Acinetobacter baumannii y otros bacilos gramnegativos no fermentadores. Enfermedades Infecciosas y Microbiología Clínica, 31(6), 402-409.
Garza-González, E., Mendoza-Ibarra, S., Llaca-Díaz, J. (2011). Molecular characterization and antimicrobial susceptibility of extended-spectrum b-lactamase producing enterobacteriaceae isolates at a tertiary care centre in Monterrey, Mexico. Journal of Medical Microbiology, 60, 84-90. https://doi.org/10.1099/jmm.0.022970-0.
Goossens, H., & Grabein, B. (2005). Prevalence and antimicrobial susceptibility data for extended-spectrum β-lactamase–and AmpC-producing Enterobacteriaceae from the MYSTIC Program in Europe and the United States (1997-2004). Diagnostic Microbiology and Infectious Disease, 53(4), 257-264. https://doi.org/10.1016/j.diagmicrobio.2005.10.001
Lavilla, S., Gonzalez-Lopez, J. J., Miro, E., Dominguez, A., Llagostera, M., Bartolome, R. M., & Prats, G. (2008). Dissemination of extended-spectrum β-lactamase-producing bacteria: The food-borne outbreak lesson. Antimicrobial Agents and Chemotherapy, 61(6), 1244-1251. https://doi.org/10.1093/jac/dkn093
Livermore, D. M., Canton, R, Gniadkowski, M., Nordmann, P., Rossolini, G. M., Arlet, G., & Woodford, N. (2007). CTX-M: changing the face of ESBLs in Europe. Journal of Antimicrobial Chemotherapy, 59(2), 165-74. https://doi.org/10.1093/jac/dkl483
Livermore, D. M., & Hawkey, P. M. (2005). CTX-M: changing the face of ESBLs in the UK. Journal of Antimicrobial Chemotherapy, 56(3), 451-4. https://doi.org/10.1093/jac/dki239
Martínez-Martínez, L., & Calvo J. (2010). The growing problem of antibiotic resistance in clinically relevant Gram-negative bacteria: current situation. Enfermedades Infecciosas y Microbiología Clínica, 2, 25-31. https://doi.org/10.1016/S0213-005X(10)70027-6
Meyer, E., Lapatschek, M., Bechtold, A., Schwarzkopf, G., Gastmeier, P., & Schwab, F. (2009). Impact of restriction of third generation cephalosporins on the burden of third generation cephalosporin resistant K. pneumoniae and E. coli in an ICU. Intensive Care Medicine, 35(5), 862-870. https://doi.org/10.1007/s00134-008-1355-6
Morfín-Otero, R., Mendoza-Olazarán, S., Silva-Sánchez, J., Garza-González, E. (2013). Characterization of Enterobacteriaceae isolates obtained from a tertiary care hospital in Mexico, which produces extended-spectrum b-lactamase. Microbial Drug Resistance, 19(5), 378-383. https://doi.org/10.1089/mdr.2012.0263
Muro, S., Garza-González, E., Camacho-Ortiz, A., González, G. M., Llaca-Díaz, J. M., Bosques, F., & Rositas, F. (2012). Risk factors associated with extended spectrum b-lactamase-producing enterobacteriaceae nosocomial bloodstream infections in a tertiary care hospital: A clinical and molecular analysis. Chemotherapy, 58(3), 217-224. https://doi.org/10.1159/000339483
NOM-017-SSA2-2012. (2013). NOM-017-SSA2-2012 para la vigilancia epidemiológica. Disponible en https://www.gob.mx/cms/uploads/attachment/file/68/NOM-017-SSA2-2012.pdf
Pérez Heras, I., Sanchez-Gomez, J. C., Beneyto-Martin, P., Ruano-de-Pablo, L., & Losada-Pinedo, B. (2017). Community-onset extended-spectrum β-lactamase producing Escherichia coli in urinary tract infections in children from 2015 to 2016: Prevalence, risk factors, and resistances. Medicine, 96(50), e8571. https://doi.org/10.1097/MD.0000000000008571.
Pitout, J. D. D., Nordmann, P., & Poirel, L. (2015). Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance. Antimicrobial Agents and Chemotherapy, 59(10), 5873-5884. https://doi.org/10.1128/AAC.01019-15.
Shaikh, S., Fatima, J., Shakil, S., Rizvi, S. M. D., & Kamal, M. A. (2015). Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. Saudi Journal of Biological Sciences, 22(1), 90-101. https://doi.org/10.1016/j.sjbs.2014.08.002
Shrivastava, S. R., Shrivastava, P. S., & Ramasamy, J. (2018). World health organization releases global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. Journal of Medical Society, 32(1), 76.
Smet, A., Martel, A., Persoons, D., Dewulf, J., Heyndrickx, M., Catry, B., & Butaye, P. (2008). Diversity of extended-spectrum β-lactamases and class C β-lactamases among cloacal Escherichia coli isolates in Belgian broiler farms. Antimicrobial Agents and Chemotherapy, 52(4), 1238-1243. https://doi.org/10.1128/AAC.01285-07
Stewart, P. S., & Costerton, J. W. (2001). Antibiotic resistance of bacteria in biofilms. The lancet, 358(9276), 135-138. https://doi.org/10.1016/S0140-6736(01)05321-1
Warren, R. E., Ensor, V. M., O’neill, P., Butler, V., Taylor, J., Nye, K. ,& Hawkey, P. M. (2008). Imported chicken meat as a potential source of quinolone-resistant Escherichia coli producing extended-spectrum β-lactamases in the UK. Journal of Antimicrobial Chemotherapy, 61(3), 504-508.
World Health Organization. (2012). The evolving threat of antimicrobial resistance: Options for action. World Health Organization.
Yanat, B., Rodríguez-Martínez, J. M., & Touati, A. (2017). Plasmid-mediated quinolone resistance in Enterobacteriaceae: A systematic review with a focus on Mediterranean countries. European Journal of Clinical Microbiology & Infectious Diseases, 36(3), 421-435. https://doi.org/10.1007/s10096-016-2847-x