La adiposidad en México: Implicaciones de las adipocinas para la función ovárica y la salud reproductiva Implicaciones de las adipocinas para la función ovárica y la salud reproductiva

Main Article Content

Itzel Ángeles Munguía
Luis Montaño
Verónica Díaz Hernández


Se destaca el efecto de la adiposidad sobre la función reproductiva, con énfasis en la acción local de algunas adipocinas sobre la función ovárica. Se realizó la revisión bibliográfica de artículos científicos. Los principales resultados de nuestra revisión son la actualización de las cifras de prevalencia de sobrepeso y obesidad en México, destacamos los efectos de la adiposidad sobre la regulación de las adipocinas para la función ovárica y la salud reproductiva. Además, evidenciamos los beneficios que se obtienen al realizar cambios en el estilo de vida. Los resultados permiten concluir que es importante visibilizar las repercusiones de la adiposidad a nivel reproductivo y se insta a la implementación de medidas que promuevan un peso saludable.

Article Details

Como citar
ÁNGELES MUNGUÍA, Itzel; MONTAÑO, Luis; DÍAZ HERNÁNDEZ, Verónica. La adiposidad en México: Implicaciones de las adipocinas para la función ovárica y la salud reproductiva. CIENCIA ergo-sum, [S.l.], v. 31, n. 3, jun. 2023. ISSN 2395-8782. Disponible en: <>. Fecha de acceso: 24 sep. 2023
Ciencias de la salud humana


Aaseth, J., Ellefsen, S., Alehagen, U., Sundfør, T. M., & Alexander, J. (2021). Diets and drugs for weight loss and health in obesity – An update. Biomedicine & Pharmacotherapy, 140, 111789.
Acquarone, E., Monacelli, F., Borghi, R., Nencioni, A., & Odetti, P. (2019). Resistin: A reappraisal. Mechanisms of Ageing and Development, 178, 46–63.
Alm, M., Soroudi, N., Wylie-Rosett, J., Isasi, C. R., Suchday, S., Rieder, J., & Khan, U. (2008). A qualitative assessment of barriers and facilitators to achieving behavior goals among obese inner-city adolescents in a weight management program. The Diabetes Educator, 34(2), 277–284.
Alnowihi, S. M., Al Doghaither, H. A., & Osman, N. N. (2020). Serum visfatin concentration and its relationship with sex hormones in obese Saudi women. International Journal of Health Sciences, 14(3), 9–13.
Argumedo, G., Taylor, J. R. L., Gaytán-González, A., González-Casanova, I., Villalobos, M. F. G., Jáuregui, A., Ulloa, E. J., Medina, C., Miranda, Y. S. P., Rodríguez, M. P., Resendiz, E., Pelayo, R. A. R., Martínez, M. D. P. R., & Galaviz, K. I. (2020). Mexico’s 2018 Report Card on Physical Activity for Children and Youth: Full report. Revista Panamericana de Salud Publica = Pan American Journal of Public Health, 44, e26.

Aye, M. M., Butler, A. E., Kilpatrick, E. S., Kirk, R., Vince, R., Rigby, A. S., Sandeman, D., & Atkin, S. L. (2018). Dynamic Change in Insulin Resistance Induced by Free Fatty Acids Is Unchanged Though Insulin Sensitivity Improves Following Endurance Exercise in PCOS. Frontiers in Endocrinology, 9.
Barbe, A., Bongrani, A., Mellouk, N., Estienne, A., Kurowska, P., Grandhaye, J., Elfassy, Y., Levy, R., Rak, A., Froment, P., & Dupont, J. (2019). Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions. International Journal of Molecular Sciences, 20(7).
Bongrani, A., Mellouk, N., Rame, C., Cornuau, M., Guérif, F., Froment, P., & Dupont, J. (2019). Ovarian Expression of Adipokines in Polycystic Ovary Syndrome: A Role for Chemerin, Omentin, and Apelin in Follicular Growth Arrest and Ovulatory Dysfunction? International Journal of Molecular Sciences, 20(15).
Bray, G. A., Heisel, W. E., Afshin, A., Jensen, M. D., Dietz, W. H., Long, M., Kushner, R. F., Daniels, S. R., Wadden, T. A., Tsai, A. G., Hu, F. B., Jakicic, J. M., Ryan, D. H., Wolfe, B. M., & Inge, T. H. (2018). The Science of Obesity Management: An Endocrine Society Scientific Statement. Endocrine Reviews, 39(2), 79–132.
Che, X., Chen, Z., Liu, M., & Mo, Z. (2021). Dietary Interventions: A Promising Treatment for Polycystic Ovary Syndrome. Annals of Nutrition & Metabolism, 77(6), 313–323.
Childs, G. V, Odle, A. K., MacNicol, M. C., & MacNicol, A. M. (2021). The Importance of Leptin to Reproduction. Endocrinology, 162(2).
Cruz Sánchez, M., Tuñón Pablos, E., Villaseñor Farías, M., Álvarez Gordillo, G. del C., & Nigh Nielsen, R. B. (2013). Sobrepeso y obesidad: una propuesta de abordaje desde la sociología. Región y Sociedad, 25(57), 165–202.
Cymbaluk-Płoska, A., Chudecka-Głaz, A., Pius-Sadowska, E., Sompolska-Rzechuła, A., Machaliński, B., & Menkiszak, J. (2018). Circulating Serum Level of Visfatin in Patients with Endometrial Cancer. BioMed Research International, 2018, 8576179.
Daquinag, A. C., Zhang, Y., Amaya-Manzanares, F., Simmons, P. J., & Kolonin, M. G. (2011). An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells. Cell Stem Cell, 9(1), 74–86.
Digournay Piedra, C., Digournay, N. S., & Perera, M. L. (2019). Influencia del sobrepeso y obesidad en el embarazo. Panorama. Cuba y Salud, 14(1), 28–32.
Dobrzyn, K., Smolinska, N., Kiezun, M., Szeszko, K., Rytelewska, E., Kisielewska, K., Gudelska, M., & Kaminski, T. (2018). Adiponectin: A New Regulator of Female Reproductive System. International Journal of Endocrinology, 2018, 7965071.
Estienne, A., Bongrani, A., Reverchon, M., Ramé, C., Ducluzeau, P.-H., Froment, P., & Dupont, J. (2019). Involvement of Novel Adipokines, Chemerin, Visfatin, Resistin and Apelin in Reproductive Functions in Normal and Pathological Conditions in Humans and Animal Models. International Journal of Molecular Sciences, 20(18).
Frigolet, M. E., & Gutiérrez-Aguilar, R. (2020). Los colores del tejido adiposo. Gaceta de México, 156(2).
Gao, X., Li, Y., Ma, Z., Jing, J., Zhang, Z., Liu, Y., & Ding, Z. (2021). Obesity induces morphological and functional changes in female reproductive system through increases in NF-κB and MAPK signaling in mice. Reproductive Biology and Endocrinology, 19(1).
Gariballa, S., Alkaabi, J., Yasin, J., & Al Essa, A. (2019). Total adiponectin in overweight and obese subjects and its response to visceral fat loss. BMC Endocrine Disorders, 19(1), 55.

Gatica-Domínguez, G., Moreno-Saracho, J. E., Cortés, J. D., Henao-Moran, S. A., & Rivera, J. A. (2018). Condición física de escolares tras intervención educativa para prevenir obesidad infantil en Morelos, México. Salud Pública de México, 61(1), 78–85.
Gelen, V., Kükürt, A., Şengül, E., & Devecı, H. A. (2021). Leptin and Its Role in Oxidative Stress and Apoptosis: An Overview. In V. Rao & L. Rao (Eds.), Role of Obesity in Human Health and Disease. IntechOpen.
Gelsomino, L., Naimo, G. D., Catalano, S., Mauro, L., & Andò, S. (2019). The Emerging Role of Adiponectin in Female Malignancies. International Journal of Molecular Sciences, 20(9).
Goldsammler, M., Merhi, Z., & Buyuk, E. (2018). Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis. Reproductive Biology and Endocrinology : RB&E, 16(1), 45.
Hu, E., Liang, P., & Spiegelman, B. M. (1996). AdipoQ is a novel adipose-specific gene dysregulated in obesity. The Journal of Biological Chemistry, 271(18), 10697–10703.
Ionescu, C. A., Popescu, I., Banacu, M., & Dimitriu, M. (2018). Lifestyle Changes and Weight Loss: Effects in PCOS. In N. K. Agrawal & K. Singh (Eds.), Debatable Topics in PCOS Patients. IntechOpen.
Jaiswar, S. P., & Priyadarshini, A. (2021). Leptin and Female Reproductive Health. In Weight Management - Challenges and Opportunities. IntechOpen.
Jáuregui, A., Pacheco-Miranda, S., Argumedo-García, G., Marrón-Ponce, J. A., G.-Olvera, A., Vargas-Meza, J., Ayvar-Gama, Y. Y., Velázquez, D., David Quezada, A., & Bonvecchio-Arenas, A. (2022). Comprehensive evaluation of Salud Escolar a health school program in Mexico: Rationale, design and methods. Preventive Medicine Reports, 25, 101662.
Kaminski, T., Kiezun, M., Zaobidna, E., Dobrzyn, K., Wasilewska, B., Mlyczynska, E., Rytelewska, E., Kisielewska, K., Gudelska, M., Bors, K., Kopij, G., Szymanska, K., Kaminska, B., Rak, A., & Smolinska, N. (2021). Plasma level and expression of visfatin in the porcine hypothalamus during the estrous cycle and early pregnancy. Scientific Reports, 11(1), 8698.
Kim, K. W. (2021). Unravelling Polycystic Ovary Syndrome and Its Comorbidities. Journal of Obesity & Metabolic Syndrome, 30(3), 209–221.
Kleine, H. D., McCormack, L. A., Drooger, A., & Meendering, J. R. (2019). Barriers to and Facilitators of Weight Management in Adults Using a Meal Replacement Program That Includes Health Coaching. Journal of Primary Care & Community Health, 10, 2150132719851643.
Kohzadi, M., Khazaei, M. R., Choobsaz, F., & Khazaei, M. (2020). Relationship between Serum Levels of Anti-Mullerian Hormone, Adiponectin and Oxidative Stress Markers in Patients with Polycystic Ovary Syndrome. International Journal of Fertility & Sterility, 14(1), 27–33.
Lee, P. C., & Dixon, J. (2017). Pharmacotherapy for obesity. Australian Family Physician, 46(7), 472–477.
Li, C., Ademiluyi, A., Ge, Y., & Park, A. (2022). Using Social Media to Understand Web-Based Social Factors Concerning Obesity: Systematic Review. JMIR Public Health Surveill, 8(3), e25552.
Lombardo, M., Perrone, M. A., Guseva, E., Aulisa, G., Padua, E., Bellia, C., Della-Morte, D., Iellamo, F., Caprio, M., & Bellia, A. (2020). Losing Weight after Menopause with Minimal Aerobic Training and Mediterranean Diet. Nutrients, 12(8).
Marrón-Ponce, J. A., Tolentino-Mayo, L., Hernández-F, M., & Batis, C. (2018). Trends in Ultra-Processed Food Purchases from 1984 to 2016 in Mexican Households. Nutrients, 11(1).
Martínez-Hernández, J. E., Suárez-Cuenca, J. A., Martínez-Meraz, M., López-Rivera, I. M., Pérez-Cabeza de Vaca, R., Mondragón-Terán, P., & Alcaraz-Estrada, S. L. (2019). Papel de la adiponectina en obesidad y diabetes tipo 2. Medicina Interna de México, 35(3), 389–396.
Mechanick, J. I., Hurley, D. L., & Garvey, W. T. (2017). Adiposity-Based Chronic Disease as a new Diagnostic Term: The American Association of Clinical Endocrinologists and American College of Endocrinology Position Statement. Endocrine Practice, 23(3), 372–378.
Medina Sifuentes, M. G., González-Torres, M. L., Salazar Garza, M. L., & Navarro Contreras, G. (2020). Apoyo y barreras sociales en el comportamiento alimentario de mujeres con obesidad. Revista Mexicana de Trastornos Alimentarios, 10(4), 359–371.
Mei, S., Ding, J., Wang, K., Ni, Z., & Yu, J. (2022). Mediterranean Diet Combined With a Low-Carbohydrate Dietary Pattern in the Treatment of Overweight Polycystic Ovary Syndrome Patients. In Frontiers in Nutrition (Vol. 9).
Mejia-Montilla, J., Reyna-Villasmil, N., Reyna-Villasmil, E., Domínguez-Brito, L., Naranjo-Rodríguez, C., Noriega-Verdugo, D., Ruiz-Polit, P., Vargas-Olalla, V., & Villavicencio-Yanos, C. (2019). Efectos del aceite de linaza sobre las concentraciones de resistina plasmática en mujeres con síndrome de ovarios poliquísticos. Revista Chilena de Obstetricia y Ginecología, 84(4), 263–276.
Merhi, Z., Bazzi, A. A., Bonney, E. A., & Buyuk, E. (2019). Role of adiponectin in ovarian follicular development and ovarian reserve. Biomedical Reports, 10, 337–342.
Messini, C. I., Vasilaki, A., Korona, E., Anifandis, G., Georgoulias, P., Dafopoulos, K., Garas, A., Daponte, A., & Messinis, I. E. (2019). Effect of resistin on estradiol and progesterone secretion from human luteinized granulosa cells in culture. Systems Biology in Reproductive Medicine, 65(5), 350–356.

Missel, A. L., O’Brien, A. V., Maser, H., Kanwal, A., Bayandorian, H., Martin, S., Carrigan, P., McNamee, R., Daubenmier, J., Isaman, D. J. M., Padmanabhan, V., Smith, Y. R., Aikens, J. E., & Saslow, L. R. (2021). Impact of an online multicomponent very-low-carbohydrate program in women with polycystic ovary syndrome: a pilot study. F&S Reports, 2(4), 386-395.
Nieuwenhuis, D., Pujol-Gualdo, N., Arnoldussen, I. A. C., & Kiliaan, A. J. (2020). Adipokines: A gear shift in puberty. Obesity Reviews : An Official Journal of the International Association for the Study of Obesity, 21(6), e13005.
Obradovic, M., Sudar-Milovanovic, E., Soskic, S., Essack, M., Arya, S., Stewart, A. J., Gojobori, T., & Isenovic, E. R. (2021). Leptin and Obesity: Role and Clinical Implication. Frontiers in Endocrinology, 12, 585887.
Orisaka, M., Miyazaki, Y., Shirafuji, A., Tamamura, C., Tsuyoshi, H., Tsang, B. K., & Yoshida, Y. (2021). The role of pituitary gonadotropins and intraovarian regulators in follicle development: A mini-review. Reproductive Medicine and Biology, 20(2), 169–175.
Panda, S. R., Jain, M., Jain, S., Saxena, R., & Hota, S. (2018). Effect of Orlistat Versus Metformin in Various Aspects of Polycystic Ovarian Syndrome: A Systematic Review of Randomized Control Trials. Journal of Obstetrics and Gynaecology of India, 68(5), 336–343.
Penzias, A., Azziz, R., Bendikson, K., Falcone, T., Hansen, K., Hill, M., Jindal, S., Kalra, S., Mersereau, J., Reindollar, R., Shannon, C. N., Steiner, A., Tanrikut, C., Taylor, H., & Yauger, B. (2021). Obesity and reproduction: a committee opinion. Fertility and Sterility, 116(5), 1266–1285.
Pereira Calvo, J., Pereira Rodríguez, Y., & Quirós Figueroa, L. (2020). Infertilidad y factores que favorecen su aparición. Revista Medica Sinergia, 5(5), e485.
Polito, R., Monda, V., Nigro, E., Messina, A., Di Maio, G., Giuliano, M. T., Orrù, S., Imperlini, E., Calcagno, G., Mosca, L., Mollica, M. P., Trinchese, G., Scarinci, A., Sessa, F., Salerno, M., Marsala, G., Buono, P., Mancini, A., Monda, M., … Messina, G. (2020). The Important Role of Adiponectin and Orexin-A, Two Key Proteins Improving Healthy Status: Focus on Physical Activity. Frontiers in Physiology, 11.
Quintanar, J. L., & Salinas, E. (2022). Papel dual de la leptina en la obesidad. Lux Médica, 17(50).
Reyes-Farias, M., Fos-Domenech, J., Serra, D., Herrero, L., & Sánchez-Infantes, D. (2021). White adipose tissue dysfunction in obesity and aging. Biochemical Pharmacology, 192, 114723.
Reyna-Villasmil, N., Montilla, J., & Reyna-Villasmil, E. (2021). Obesidad, complicaciones del embarazo y salud femenina a largo plazo. Revista de Obstetricia y Ginecología de Venezuela, 81(2), 162–169.
Rodríguez-Torres, A., & Casas-Patiño, D. (2018). Determinantes sociales de la obesidad en México Social determinants of obesity in Mexico. Rev Enferm Inst Mex Seguro Soc, 26(4), 281-290.
Rodriguez-Ventura, A., Parra-Solano, A., Illescas-Zárate, D., Hernández-Flores, M., Paredes, C., Flores-Cisneros, C., Sánchez, B., Tolentino, M., Sámano, R., & Chinchilla, D. (2018). “Sacbe”, a Comprehensive Intervention to Decrease Body Mass Index in Children with Adiposity: A Pilot Study. International Journal of Environmental Research and Public Health, 15(9).
Rongvaux, A., Shea, R. J., Mulks, M. H., Gigot, D., Urbain, J., Leo, O., & Andris, F. (2002). Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. European Journal of Immunology, 32(11), 3225–3234.<3225::AID-IMMU3225>3.0.CO;2-L
Saeidi, A., Jabbour, G., Ahmadian, M., Abbassi-Daloii, A., Malekian, F., Hackney, A. C., Saedmocheshi, S., Basati, G., Ben Abderrahman, A., & Zouhal, H. (2019). Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women. Frontiers in Physiology, 10, 484.
Samal, B., Sun, Y., Stearns, G., Xie, C., Suggs, S., & McNiece, I. (1994). Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Molecular and Cellular Biology, 14(2), 1431–1437.
Sánchez-Solana, B., Laborda, J., & Baladrón, V. (2012). Mouse Resistin Modulates Adipogenesis and Glucose Uptake in 3T3-L1 Preadipocytes Through the ROR1 Receptor. Molecular Endocrinology, 26(1), 110–127.
Scherer, P. E., Williams, S., Fogliano, M., Baldini, G., & Lodish, H. F. (1995). A novel serum protein similar to C1q, produced exclusively in adipocytes. The Journal of Biological Chemistry, 270(45), 26746–26749.
Seibold, E. S., Knafl, K., & Grey, M. (2003). The family context of an intervention to prevent type 2 diabetes in high-risk teens. The Diabetes Educator, 29(6), 997–1004.
Seifarth, C., Schehler, B., & Schneider, H. J. (2013). Effectiveness of metformin on weight loss in non-diabetic individuals with obesity. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 121(1), 27–31.
Shamah-Levy, T., Romero-Martínez, M., Barrientos-Gutiérrez, T., Cuevas-Nasu, L., Bautista-Arredondo, S., Colchero, M., Gaona- Pineda, E., Lazcano-Ponce, E., Martínez-Barnetche, J., Alpuche-Arana, C., & Rivera-Dommarco, J. (2021). Encuesta Nacional de Salud y Nutrición 2020 sobre Covid-19. Resultados nacionales. Cuernavaca, México: Instituto Nacional de Salud Pública, 2021.
Shishehgar, F., Mirmiran, P., Rahmati, M., Tohidi, M., & Ramezani Tehrani, F. (2019). Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? BMC Endocrine Disorders, 19(1), 93.
Silvestris, E., de Pergola, G., Rosania, R., & Loverro, G. (2018). Obesity as disruptor of the female fertility. Reproductive Biology and Endocrinology, 16(1), 22.
Soltero, E. G., Ayers, S. L., Avalos, M. A., Peña, A., Williams, A. N., Olson, M. L., Konopken, Y. P., Castro, F. G., Arcoleo, K. J., Keller, C. S., Patrick, D. L., Jager, J., & Shaibi, G. Q. (2021). Theoretical Mediators of Diabetes Risk and Quality of Life Following a Diabetes Prevention Program for Latino Youth With Obesity. American Journal of Health Promotion : AJHP, 35(7), 939–947.
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001). The hormone resistin links obesity to diabetes. Nature, 409(6818), 307–312.
Steppan, C. M., Brown, E. J., Wright, C. M., Bhat, S., Banerjee, R. R., Dai, C. Y., Enders, G. H., Silberg, D. G., Wen, X., Wu, G. D., & Lazar, M. A. (2001). A family of tissue-specific resistin-like molecules. Proceedings of the National Academy of Sciences of the United States of America, 98(2), 502–506.
Straub, L. G., & Scherer, P. E. (2019). Metabolic Messengers: Adiponectin. Nature Metabolism, 1(3), 334–339.
Tenedero, C. B., Oei, K., & Palmert, M. R. (2022). An Approach to the Evaluation and Management of the Obese Child With Early Puberty. Journal of the Endocrine Society, 6(1), bvab173.
Torres-Lobatón, A., Barra-Martínez, R., Jiménez-Arroyo, E. P., Portillo-Reyes, J., Suárez-Juárez, C. A., & Morgan-Ortiz, F. (2020). Obesidad y cáncer de endometrio: las repercusiones de un problema de salud pública. Ginecología y Obstetricia de México, 88(9), 569–574.
Torres, F., & Rojas, A. (2018). Obesidad y salud pública en México: transformación del patrón hegemónico de oferta-demanda de alimentos. Problemas Del Desarrollo, 49(193), 145–169.
Valenzuela, R., Morales, A., Sheen, J., Rangel, S., & Salinas, J. J. (2021). The Implementation of Evidence-Based Obesity Education Curricula to Prevent Cancer in a Predominantly Mexican-American Community on the U.S.-Mexico Border. Journal of Cancer Education : The Official Journal of the American Association for Cancer Education, 1–10.
Valero, P., Souki, A., Arraiz Rodríguez, N., Prieto, C., & Cano-Ponce, C. (2018). Resistina y otras adipoquinas: papel en la obesidad, diabetes e insulinoresistencia. In V. Bermúdez- Pirela & Y. Herazo-Beltrán (Eds.), Aspectos básicos en obesidad (pp. 19–59). Barranquilla, Colombia: Ediciones Universidad Simón Bolívar.
Vázquez-Velázquez, V., Laviada-Molina, H., García-García, E., Sandoval-Diez, E., & Mancillas-Adame, L. (2021). Perceptions, Attitudes, and Barriers to Obesity Care in Mexico: Data From the ACTION-IO Study. Obesity (Silver Spring, Md.), 29(2), 317–326.
Wang, H., Zhu, S., Wu, X., Liu, Y., Ge, J., Wang, Q., & Gu, L. (2021). NAMPT reduction-induced NAD(+) insufficiency contributes to the compromised oocyte quality from obese mice. Aging Cell, 20(11), e13496.
Weschenfelder, J., Bentley, J., & Himmerich, H. (2018). Physical and Mental Health Consequences of Obesity in Women. In L. Szablewski (Ed.), Adipose Tissue. IntechOpen.
Wołodko, K., Castillo-Fernandez, J., Kelsey, G., & Galvão, A. (2021). Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers. International Journal of Molecular Sciences, 22(8).
World Obesity Federation. (2022). Global Obesity Observatory. México.