Synthetic Biology and the Boost of COVID-19 Vaccines Technology Development through International Alliances
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The importance of the development of the necessary technology to achieve the production of vaccines from a “synthetic biology” perspective is analyzed, as well as the essential articulation and financing through international cooperation to combat COVID-19, all the information on this topic is from the bibliographical research on topics focused on the development, cooperation, and international regulations involved in the synthesis of COVID-19 vaccines. A comprehensive vision on the recent development strategies on health and bioeconomy issues is proposed to face future eventualities and thus promote better health-oriented developments with the possibilities of immediate action.
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MUÑOZ-MIRANDA, Luis Alfonso; ARREOLA-HERNÁNDEZ, Ana Sofía; FIGUEROA-YÁÑEZ, Luis Joel.
Synthetic Biology and the Boost of COVID-19 Vaccines Technology Development through International Alliances.
CIENCIA ergo-sum, [S.l.], v. 29, n. 4, dic. 2022.
ISSN 2395-8782.
Disponible en: <https://cienciaergosum.uaemex.mx/article/view/18695>. Fecha de acceso: 06 feb. 2025
doi: https://doi.org/10.30878/ces.v29n4a5.
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Esta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial-SinObrasDerivadas 4.0.
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Abdellatif, A. A. H., Tawfeek, H. M., Abdelfattah, A., El-Saber Batiha, G., & Hetta, H. F. (2021). Recent updates in COVID-19 with emphasis on inhalation therapeutics: Nanostructured and targeting systems. Journal of Drug Delivery Science and Technology, 63, 102435. https://doi.org/10.1016/j.jddst.2021.102435
Boles, K. S., Kannan, K., Gill, J., Felderman, M., Gouvis, H., Hubby, B., Kamrud, K. I., Venter, J. C., & Gibson, D. G. (2017). Digital-to-biological converter for on-demand production of biologics. Nature Biotechnology, 35(7), 672-675. https://doi.org/10.1038/nbt.3859
Brooks, S. M., & Alper, H. S. (2021). Applications, challenges, and needs for employing synthetic biology beyond the lab. Nature Communications, 12(1), 1-16. https://doi.org/10.1038/s41467-021-21740-0.
CEPI (2021a). New vaccines for a safer world. Retrieved from https://cepi.net/
CEPI (2021b). Platform Technologies. Retrieved from https://cepi.net/research_dev/technology/.
Christodoulou, M. (2018). CEPI partners with Imperial College to develop transformative rapid-response technology to create vaccines against emerging infectious diseases. Retrieved from https://cepi.net/news_cepi/cepi-partners-with-imperial-college-to-develop-transformative-rapid-response-technology-to-create-vaccines-against-emerging-infectious-diseases/.
Clarke, L. (2020). Synthetic biology, engineering biology, market expectation. Engineering Biology, 4(3), 33-36. https://doi.org/10.1049/enb.2020.0021.
Codex DNA (2020). Meet the BIOXPTM 3250 system, our new automated synthetic biology workstation. Retrieved from https://codexdna.com/2020/08/26/meet-the-bioxp-3250-system-our-new-automated-synthetic-biology-workstation/
Cumbers, J. (2020). Synthetic biology versus coronavirus: Three women in a cutting-edge field using biological engineering to save lives. FORBES. Retrieved from https://www.forbes.com/sites/johncumbers/2020/09/10/synthetic-biology-versus-coronavirus-three-women/?sh=9ac460ddf08d
Dinnes, J., Deeks, J. J., Berhane, S., Taylor, M., Adriano, A., Davenport, C., Dittrich, S., Emperador, D., Takwoingi, Y., ... & Cochrane COVID-19 Diagnostic Test Accuracy Group (2021). Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection. Cochrane Database of Systematic Reviews, 8(8), CD013705. https://doi.org/10.1002/14651858.CD013705.pub2.
Dolgin, E. (2020, September 28). Synthetic biology speeds vaccine development. Nature. Retrieved from https://www.nature.com/articles/d42859-020-00025-4#:~:text=Craig%20Venter%20Institute%20and%20Synthetic,in%20a%20matter%20of%20days.
Dolgin, E. (2021, January 12). How COVID unlocked the power of mRNA. Nature. Retrieved from https://www.nature.com/articles/d41586-021-00019-w
Forni, G., Mantovani, A., Forni, G., Mantovani, A., Moretta, L., Rappuoli, R., Rezza, G., Bagnasco, A., Barsacchi, G., Bussolati, G., … COVID-19 Commission of Accademia Nazionale dei Lincei (2021). COVID-19 vaccines: Where we stand and challenges ahead. Cell Death and Differentiation, 28, 626-639. https://doi.org/10.1038/s41418-020-00720-9.
Ghattas, M., Dwivedi, G., Lavertu, M., & Alameh, M. G. (2021). Vaccine technologies and platforms for infectious diseases: Current progress, challenges, and opportunities. Vaccines, 9(12), 1490. https://doi.org/10.3390/vaccines9121490.
Haynes, B. F. (2021). A new vaccine to battle Covid-19. The New England Journal of Medicine, 384(5). https://doi.org/10.1056/nejme2035557.
IFPMA (International Federation of Pharmaceutical Manufacturers and Associations). (2020). IFPMA Policy Principles on COVID-19. Vaccines Initiative. Retrieved from https://www.ifpma.org/wp-content/uploads/2020/09/IFPMA-Policy-Principles-on-COVID-19-Vaccines-Initiative.pdf
Katz, N., Tripto, E., Granik, N., Goldberg, S., Atar, O., Yakhini, Z., Orenstein, Y., & Amit, R. (2021). Overcoming the design, build, test bottleneck for synthesis of nonrepetitive protein-RNA cassettes. Nature Communications, 12, 1576. https://doi.org/10.1038/s41467-021-21578-6
Kelwick, R. J. R., Webb, A. J., & Freemont, P. S. (2020). Biological Materials: The Next Frontier for Cell-Free Synthetic Biology. Frontiers in Bioengineering and Biotechnology, 8, 399. https://doi.org/ 10.3389/fbioe.2020.00399
Kohn, J. (2004). New approaches to biomaterials design. Nature Materials, 3, 745-747. https://doi.org/10.1038/nmat1249.
Li, J., Zhao, H., Zheng, L., & An, W. (2021). Advances in synthetic biology and biosafety governance. Frontiers in Bioengineering and Biotechnology, 9, 598087. https://doi.org/10.3389/fbioe.2021.598087
National Academies of Sciences, Engineering, and Medicine. (2018). Biotechnology in the Age of Synthetic Biology. In Biodefense in the Age of Synthetic Biology. Washington: National Academies Press. https://doi.org/10.17226/24890
Philippidis, A. (2021, July 2). Top 10 Synthetic Biology Companies. Genetic Engineering & Biotechnology News. Retrieved from https://www.genengnews.com/a-lists/top-10-synthetic-biology-companies/.
Pushparajah, D., Jimenez, S., Wong, S., Alattas, H., Nafissi, N., & Slavcev, R. A. (2021). Advances in gene-based vaccine platforms to address the COVID-19 pandemic. Advanced Drug Delivery Reviews, 170, 113-141. https://doi.org/10.1016/j.addr.2021.01.003
Rappuoli, R., De Gregorio, E., Del Giudice, G., Phogat, S., Pecceta, S., Pizza. M., & Hannon, E. (2021). Vaccinology in the post-COVID-19 era. Proceedings of the National Academy of Sciences, 118(3), e2020368118. https://doi.org/10.1073/pnas.2020368118
Rastogi, M., Pandey, N., Shukla, A. & Singh, S. K. (2020). SARS coronavirus 2: from genome to infectome. Respiratory Research, 21(318), 1-15. https://doi.org/10.1186/s12931-020-01581-z
Sadighbayan, D., & Ghafar-Zadeh, E. (2021). Portable Sensing Devices for Detection of COVID-19: A Review. IEEE Sensors Journal, 21(9), 10219-10230. https://doi.org/10.1109/JSEN.2021.3059970
Tan, X., Letendre, J. H., Collins, J. J., & Wong, W. W. (2021). Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics. Cell, 184(4), 881-898. https://doi.org/10.1016/j.cell.2021.01.017
Ulmer, J. B., Mansoura, M. K., & Geall, A. J. (2015). Vaccines “on demand”: Science fiction or a future reality. Expert Opinion on Drug Discovery, 10(2), 101-106. https://doi.org/10.1517/17460441.2015.996128
WHO (World Health Organization). (2021). COVAX: colaboración para un acceso equitativo mundial a las vacunas contra la COVID-19. Retrieved from https://www.who.int/es/initiatives/act-accelerator/covax
WHO (World Health Organization). (2020). Declaración conjunta OMS-ICMRA sobre la necesidad de contar con una armonización normativa mundial mejorada en lo concerniente a medicamentos y vacunas contra la COVID-19. Disponible en https://www.who.int/es/news/item/06-11-2020-who-icmra-joint-statement-on-the-need-for-improved-global-regulatory-alignment-on-covid-19-medicines-and-vaccines
Boles, K. S., Kannan, K., Gill, J., Felderman, M., Gouvis, H., Hubby, B., Kamrud, K. I., Venter, J. C., & Gibson, D. G. (2017). Digital-to-biological converter for on-demand production of biologics. Nature Biotechnology, 35(7), 672-675. https://doi.org/10.1038/nbt.3859
Brooks, S. M., & Alper, H. S. (2021). Applications, challenges, and needs for employing synthetic biology beyond the lab. Nature Communications, 12(1), 1-16. https://doi.org/10.1038/s41467-021-21740-0.
CEPI (2021a). New vaccines for a safer world. Retrieved from https://cepi.net/
CEPI (2021b). Platform Technologies. Retrieved from https://cepi.net/research_dev/technology/.
Christodoulou, M. (2018). CEPI partners with Imperial College to develop transformative rapid-response technology to create vaccines against emerging infectious diseases. Retrieved from https://cepi.net/news_cepi/cepi-partners-with-imperial-college-to-develop-transformative-rapid-response-technology-to-create-vaccines-against-emerging-infectious-diseases/.
Clarke, L. (2020). Synthetic biology, engineering biology, market expectation. Engineering Biology, 4(3), 33-36. https://doi.org/10.1049/enb.2020.0021.
Codex DNA (2020). Meet the BIOXPTM 3250 system, our new automated synthetic biology workstation. Retrieved from https://codexdna.com/2020/08/26/meet-the-bioxp-3250-system-our-new-automated-synthetic-biology-workstation/
Cumbers, J. (2020). Synthetic biology versus coronavirus: Three women in a cutting-edge field using biological engineering to save lives. FORBES. Retrieved from https://www.forbes.com/sites/johncumbers/2020/09/10/synthetic-biology-versus-coronavirus-three-women/?sh=9ac460ddf08d
Dinnes, J., Deeks, J. J., Berhane, S., Taylor, M., Adriano, A., Davenport, C., Dittrich, S., Emperador, D., Takwoingi, Y., ... & Cochrane COVID-19 Diagnostic Test Accuracy Group (2021). Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection. Cochrane Database of Systematic Reviews, 8(8), CD013705. https://doi.org/10.1002/14651858.CD013705.pub2.
Dolgin, E. (2020, September 28). Synthetic biology speeds vaccine development. Nature. Retrieved from https://www.nature.com/articles/d42859-020-00025-4#:~:text=Craig%20Venter%20Institute%20and%20Synthetic,in%20a%20matter%20of%20days.
Dolgin, E. (2021, January 12). How COVID unlocked the power of mRNA. Nature. Retrieved from https://www.nature.com/articles/d41586-021-00019-w
Forni, G., Mantovani, A., Forni, G., Mantovani, A., Moretta, L., Rappuoli, R., Rezza, G., Bagnasco, A., Barsacchi, G., Bussolati, G., … COVID-19 Commission of Accademia Nazionale dei Lincei (2021). COVID-19 vaccines: Where we stand and challenges ahead. Cell Death and Differentiation, 28, 626-639. https://doi.org/10.1038/s41418-020-00720-9.
Ghattas, M., Dwivedi, G., Lavertu, M., & Alameh, M. G. (2021). Vaccine technologies and platforms for infectious diseases: Current progress, challenges, and opportunities. Vaccines, 9(12), 1490. https://doi.org/10.3390/vaccines9121490.
Haynes, B. F. (2021). A new vaccine to battle Covid-19. The New England Journal of Medicine, 384(5). https://doi.org/10.1056/nejme2035557.
IFPMA (International Federation of Pharmaceutical Manufacturers and Associations). (2020). IFPMA Policy Principles on COVID-19. Vaccines Initiative. Retrieved from https://www.ifpma.org/wp-content/uploads/2020/09/IFPMA-Policy-Principles-on-COVID-19-Vaccines-Initiative.pdf
Katz, N., Tripto, E., Granik, N., Goldberg, S., Atar, O., Yakhini, Z., Orenstein, Y., & Amit, R. (2021). Overcoming the design, build, test bottleneck for synthesis of nonrepetitive protein-RNA cassettes. Nature Communications, 12, 1576. https://doi.org/10.1038/s41467-021-21578-6
Kelwick, R. J. R., Webb, A. J., & Freemont, P. S. (2020). Biological Materials: The Next Frontier for Cell-Free Synthetic Biology. Frontiers in Bioengineering and Biotechnology, 8, 399. https://doi.org/ 10.3389/fbioe.2020.00399
Kohn, J. (2004). New approaches to biomaterials design. Nature Materials, 3, 745-747. https://doi.org/10.1038/nmat1249.
Li, J., Zhao, H., Zheng, L., & An, W. (2021). Advances in synthetic biology and biosafety governance. Frontiers in Bioengineering and Biotechnology, 9, 598087. https://doi.org/10.3389/fbioe.2021.598087
National Academies of Sciences, Engineering, and Medicine. (2018). Biotechnology in the Age of Synthetic Biology. In Biodefense in the Age of Synthetic Biology. Washington: National Academies Press. https://doi.org/10.17226/24890
Philippidis, A. (2021, July 2). Top 10 Synthetic Biology Companies. Genetic Engineering & Biotechnology News. Retrieved from https://www.genengnews.com/a-lists/top-10-synthetic-biology-companies/.
Pushparajah, D., Jimenez, S., Wong, S., Alattas, H., Nafissi, N., & Slavcev, R. A. (2021). Advances in gene-based vaccine platforms to address the COVID-19 pandemic. Advanced Drug Delivery Reviews, 170, 113-141. https://doi.org/10.1016/j.addr.2021.01.003
Rappuoli, R., De Gregorio, E., Del Giudice, G., Phogat, S., Pecceta, S., Pizza. M., & Hannon, E. (2021). Vaccinology in the post-COVID-19 era. Proceedings of the National Academy of Sciences, 118(3), e2020368118. https://doi.org/10.1073/pnas.2020368118
Rastogi, M., Pandey, N., Shukla, A. & Singh, S. K. (2020). SARS coronavirus 2: from genome to infectome. Respiratory Research, 21(318), 1-15. https://doi.org/10.1186/s12931-020-01581-z
Sadighbayan, D., & Ghafar-Zadeh, E. (2021). Portable Sensing Devices for Detection of COVID-19: A Review. IEEE Sensors Journal, 21(9), 10219-10230. https://doi.org/10.1109/JSEN.2021.3059970
Tan, X., Letendre, J. H., Collins, J. J., & Wong, W. W. (2021). Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics. Cell, 184(4), 881-898. https://doi.org/10.1016/j.cell.2021.01.017
Ulmer, J. B., Mansoura, M. K., & Geall, A. J. (2015). Vaccines “on demand”: Science fiction or a future reality. Expert Opinion on Drug Discovery, 10(2), 101-106. https://doi.org/10.1517/17460441.2015.996128
WHO (World Health Organization). (2021). COVAX: colaboración para un acceso equitativo mundial a las vacunas contra la COVID-19. Retrieved from https://www.who.int/es/initiatives/act-accelerator/covax
WHO (World Health Organization). (2020). Declaración conjunta OMS-ICMRA sobre la necesidad de contar con una armonización normativa mundial mejorada en lo concerniente a medicamentos y vacunas contra la COVID-19. Disponible en https://www.who.int/es/news/item/06-11-2020-who-icmra-joint-statement-on-the-need-for-improved-global-regulatory-alignment-on-covid-19-medicines-and-vaccines